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Psystrike is Mewtwo's Final Smash. Mewtwo Mega Evolves into Mega Mewtwo Y and launches a large energy ball in a forward direction. Any opponent who comes in contact with the sphere will be briefly stunned before getting hit with lightning bolts and thrown back by a huge explosion. The energy ball can pierce through shielded opponents.

Origin

Psystrike is Mewtwo's signature move, introduced in Generation V. It is considered to be a stronger form of Psyshock. It is a Psychic-Type attack that has a base power of 100, making it an extremely powerful attack. Psystrike is also unique in which it calculates damage using the user's Special Attack and the opponent's Defense stat instead of the opponent's Special Defense. In its Final Smash, Mewtwo also Mega Evolves into Mega Mewtwo Y (which is not required in the Pokemon games).

Psystrike

Lucario gets hit by Psystrike

Trophy Description

Mewtwo's Final Smash starts as Mewtwo Mega Evolves into Mega Mewtwo Y. It then fires a huge psychic projectile that penetrates enemies and obstacles. This projectile doesn't do any damage, but it freezes every foe it hits in place. They can even be frozen midjump! Afterward, every foe hit with the projectile will take a powerful psychic hit to the head. 

Mewtwo's Special Moves
Melee SSBWU/3DS
Standard Special Shadow Ball
Side Special Confusion
Up Special Teleport
Down Special Disable
Final Smash Psystrike